8.3M XNYS Volume
XNYS 21 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Girish Venkatachaliah | Chief Technology Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 14 Mar 2025 | 9,429 | 158,431 | - | - | Common Stock | |
| Girish Venkatachaliah | Chief Technology Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 4.05 per share. | 14 Mar 2025 | 3,311 | 155,120 | - | 4.1 | 13,410 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 14 Mar 2025 | 11,786 | 461,201 | - | - | Common Stock | |
| Benjamin Shaker | Chief Markets Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 4.05 per share. | 14 Mar 2025 | 4,143 | 457,058 | - | 4.0 | 16,779 | Common Stock |
| Steven J. Sell | Director, CEO & President | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 14 Mar 2025 | 42,426 | 370,873 | - | - | Common Stock | |
| Steven J. Sell | Director, CEO & President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 4.05 per share. | 14 Mar 2025 | 15,563 | 355,310 | - | 4.0 | 63,030 | Common Stock |
| Karen McLoughlin A. | Director | Purchase of securities on an exchange or from another person at price $ 2.20 per share. | 13 Dec 2024 | 25,000 | 73,166 | - | 2.2 | 55,085 | Common Stock |
| Silvana Battaglia | Director | Purchase of securities on an exchange or from another person at price $ 2.01 per share. | 11 Dec 2024 | 25,062 | 66,144 | - | 2.0 | 50,269 | Common Stock |
| John William Wulf | Director | Purchase of securities on an exchange or from another person at price $ 2.18 per share. | 05 Dec 2024 | 45,000 | 206,133 | - | 2.2 | 98,145 | Common Stock |
| Diana L. McKenzie | Director | Purchase of securities on an exchange or from another person at price $ 2.28 per share. | 25 Nov 2024 | 12,500 | 51,319 | - | 2.3 | 28,474 | Common Stock |
| Diana L. McKenzie | Director | Purchase of securities on an exchange or from another person at price $ 2.20 per share. | 25 Nov 2024 | 7,500 | 58,819 | - | 2.2 | 16,489 | Common Stock |
| Steven J. Sell | Director, CEO & President | Purchase of securities on an exchange or from another person at price $ 3.36 per share. | 12 Sep 2024 | 20,000 | 67,590 | - | 3.4 | 67,188 | Common Stock |
| Timothy Gertsch | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 4.85 per share. | 16 Aug 2024 | 405 | 57,947 | - | 4.8 | 1,964 | Common Stock |
| Jeffrey A. Schwaneke | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 377,074 | 441,124 | - | 0 | Common Stock | |
| Jeffrey A. Schwaneke | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 131,976 | 573,100 | - | 0 | Common Stock | |
| Jeffrey A. Schwaneke | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 150,830 | 723,930 | - | 0 | Common Stock | |
| Jeffrey A. Schwaneke | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jul 2024 | 239,072 | 239,072 | - | - | Options (Rights to Buy) | |
| Silvana Battaglia | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 May 2024 | 32,119 | 41,082 | - | 0 | Common Stock | |
| John William Wulf | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 May 2024 | 32,119 | 161,133 | - | 0 | Common Stock | |
| Jeffrey A. Schwaneke | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 May 2024 | 32,119 | 64,050 | - | 0 | Common Stock | |
| Ronald A. Williams | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 May 2024 | 32,119 | 3,596,533 | - | 0 | Common Stock | |
| Sharad S. Mansukani | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 May 2024 | 32,119 | 1,274,033 | - | 0 | Common Stock | |
| Karen A. McLoughlin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 May 2024 | 32,119 | 48,166 | - | 0 | Common Stock | |
| Diana L. McKenzie | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 May 2024 | 32,119 | 38,819 | - | 0 | Common Stock | |
| Timothy Gertsch | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 6.09 per share. | 24 May 2024 | 187 | 57,760 | - | 6.1 | 1,139 | Common Stock |
| Steven J. Sell | Director, CEO & President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2024 | 415,130 | 415,130 | - | - | Options (Right to buy) | |
| Steven J. Sell | Director, CEO & President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2024 | 252,243 | 336,322 | - | 0 | Common Stock | |
| Steven J. Sell | Director, CEO & President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 4.95 per share. | 14 Apr 2024 | 7,875 | 328,447 | - | 4.9 | 38,981 | Common Stock |
| Timothy S. Bensley | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 4.95 per share. | 14 Apr 2024 | 3,978 | 39,387 | - | 4.9 | 19,691 | Common Stock |
| Veeral Desai | Chief Strategy & Dev. Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2024 | 196,189 | 502,830 | - | 0 | Common Stock | |
| Veeral Desai | Chief Strategy & Dev. Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2024 | 322,879 | 322,879 | - | - | Options (Right to buy) | |
| Veeral Desai | Chief Strategy & Dev. Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 4.95 per share. | 14 Apr 2024 | 4,817 | 498,013 | - | 4.9 | 23,844 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2024 | 322,879 | 322,879 | - | - | Options (Right to buy) | |
| Benjamin Shaker | Chief Markets Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 4.95 per share. | 14 Apr 2024 | 5,506 | 449,415 | - | 5.0 | 27,255 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2024 | 196,189 | 454,921 | - | 0 | Common Stock | |
| Girish Venkatachaliah | Chief Technology Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2024 | 112,108 | 152,058 | - | 0 | Common Stock | |
| Girish Venkatachaliah | Chief Technology Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 4.95 per share. | 14 Apr 2024 | 3,056 | 149,002 | - | 4.9 | 15,127 | Common Stock |
| Girish Venkatachaliah | Chief Technology Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2024 | 184,502 | 184,502 | - | - | Options (Right to buy) | |
| Timothy Gertsch | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2024 | 69,189 | 69,189 | - | - | Options (Right to buy) | |
| Timothy Gertsch | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2024 | 42,041 | 59,162 | - | 0 | Common Stock | |
| Timothy Gertsch | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 4.95 per share. | 14 Apr 2024 | 810 | 58,352 | - | 5.0 | 4,010 | Common Stock |
| Timothy S. Bensley | Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 14 Mar 2024 | 14,945 | 50,116 | - | - | Common Stock | |
| Timothy S. Bensley | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 5.23 per share. | 14 Mar 2024 | 6,751 | 43,365 | - | 5.2 | 35,308 | Common Stock |
| Veeral Desai | Chief Strategy & Dev. Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 14 Mar 2024 | 11,956 | 311,541 | - | - | Common Stock | |
| Veeral Desai | Chief Strategy & Dev. Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 5.23 per share. | 14 Mar 2024 | 4,900 | 306,641 | - | 5.2 | 25,627 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 5.23 per share. | 14 Mar 2024 | 1,883 | 62,058 | - | 5.2 | 9,848 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 14 Mar 2024 | 5,434 | 63,941 | - | - | Common Stock | |
| Benjamin Shaker | Chief Markets Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 5.23 per share. | 14 Mar 2024 | 95,266 | 258,732 | - | 5.2 | 498,241 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 14 Mar 2024 | 274,455 | 353,998 | - | - | Common Stock | |
| Girish Venkatachaliah | Chief Technology Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 14 Mar 2024 | 5,434 | 41,833 | - | - | Common Stock | |
| Girish Venkatachaliah | Chief Technology Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 5.23 per share. | 14 Mar 2024 | 1,883 | 39,950 | - | 5.2 | 9,848 | Common Stock |
| A. Williams Ronald | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.00 per share. | 05 Jan 2024 | 150,000 | 3,564,414 | - | 3 | 450,000 | Common Stock |
| Ronald Williams A. | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.00 per share. | 05 Jan 2024 | 950,000 | 3,414,414 | - | 1 | 950,000 | Common Stock |
| A. Williams Ronald | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jan 2024 | 950,000 | 0 | - | - | Options (Rights to Buy) | |
| Ronald A. Williams | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jan 2024 | 150,000 | 0 | - | - | Options (Rights to Buy) | |
| Jeffrey A. Schwaneke | Director | Purchase of securities on an exchange or from another person at price $ 11.22 per share. | 29 Nov 2023 | 22,300 | 31,931 | - | 11.2 | 250,206 | Common Stock |
| Steven J. Sell | Director, CEO & President | Purchase of securities on an exchange or from another person at price $ 11.14 per share. | 21 Nov 2023 | 44,690 | 47,590 | - | 11.1 | 497,739 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 18.00 per share. | 12 Sep 2023 | 18,750 | 79,543 | - | 18.0 | 337,455 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.79 per share. | 12 Sep 2023 | 18,750 | 98,293 | - | 3.8 | 71,063 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.79 per share. | 12 Sep 2023 | 18,750 | 98,293 | - | 3.8 | 71,063 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 18.05 per share. | 12 Sep 2023 | 18,750 | 79,543 | - | 18.1 | 338,481 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Sep 2023 | 18,750 | 301,851 | - | - | Options (Right to buy) | |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Sep 2023 | 18,750 | 320,601 | - | - | Options (Right to buy) | |
| Timothy Gertsch | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 18.62 per share. | 11 Sep 2023 | 17,500 | 17,121 | - | 18.6 | 325,778 | Common Stock |
| Timothy Gertsch | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Sep 2023 | 8,750 | 8,750 | - | - | Options (Rights to Buy) | |
| Timothy Gertsch | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Sep 2023 | 17,500 | 8,750 | - | - | Options (Rights to Buy) | |
| Timothy Gertsch | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 18.61 per share. | 11 Sep 2023 | 8,750 | 17,121 | - | 18.6 | 162,838 | Common Stock |
| Timothy Gertsch | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.50 per share. | 11 Sep 2023 | 8,750 | 25,871 | - | 4.5 | 39,375 | Common Stock |
| Timothy Gertsch | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.99 per share. | 11 Sep 2023 | 17,500 | 34,621 | - | 9.0 | 157,325 | Common Stock |
| Timothy Gertsch | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Aug 2023 | 9,709 | 9,709 | - | - | Options (Rights to Buy) | |
| Timothy Gertsch | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Aug 2023 | 5,603 | 17,121 | - | 0 | Common Stock | |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 18.72 per share. | 14 Aug 2023 | 18,750 | 79,543 | - | 18.7 | 351,083 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Aug 2023 | 18,750 | 339,351 | - | - | Options (Right to buy) | |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Aug 2023 | 18,750 | 358,101 | - | - | Options (Right to buy) | |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 18.10 per share. | 14 Aug 2023 | 18,750 | 79,543 | - | 18.1 | 339,309 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.79 per share. | 14 Aug 2023 | 18,750 | 98,293 | - | 3.8 | 71,063 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.79 per share. | 14 Aug 2023 | 18,750 | 98,293 | - | 3.8 | 71,063 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 16.97 per share. | 12 Jul 2023 | 18,750 | 79,543 | - | 17.0 | 318,182 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jul 2023 | 18,750 | 376,851 | - | - | Options (Right to buy) | |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jul 2023 | 18,750 | 395,601 | - | - | Options (Right to buy) | |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 16.93 per share. | 12 Jul 2023 | 18,750 | 79,543 | - | 16.9 | 317,424 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.79 per share. | 12 Jul 2023 | 18,750 | 98,293 | - | 3.8 | 71,063 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.79 per share. | 12 Jul 2023 | 18,750 | 98,293 | - | 3.8 | 71,063 | Common Stock |
| Silvana Battaglia | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2023 | 19,251 | 19,251 | - | - | Options (Right to buy) | |
| Silvana Battaglia | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Jun 2023 | 8,963 | 8,963 | - | 0 | Common Stock | |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 17.93 per share. | 14 Jun 2023 | 1,851 | 79,543 | - | 17.9 | 33,194 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Jun 2023 | 18,750 | 414,351 | - | - | Options (Right to buy) | |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Jun 2023 | 1,100 | 433,101 | - | - | Options (Right to buy) | |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Jun 2023 | 15,799 | 434,201 | - | - | Options (Right to buy) | |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Jun 2023 | 1,851 | 0 | - | - | Options (Right to buy) | |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 18.73 per share. | 14 Jun 2023 | 18,750 | 79,543 | - | 18.7 | 351,103 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.79 per share. | 14 Jun 2023 | 18,750 | 98,293 | - | 3.8 | 71,063 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 19.17 per share. | 14 Jun 2023 | 1,100 | 79,543 | - | 19.2 | 21,084 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.79 per share. | 14 Jun 2023 | 1,100 | 80,643 | - | 3.8 | 4,169 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 18.60 per share. | 14 Jun 2023 | 15,799 | 79,543 | - | 18.6 | 293,868 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.79 per share. | 14 Jun 2023 | 15,799 | 95,342 | - | 3.8 | 59,878 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.00 per share. | 14 Jun 2023 | 1,851 | 81,394 | - | 3 | 5,553 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.00 per share. | 15 May 2023 | 25,000 | 104,543 | - | 3 | 75,000 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 May 2023 | 25,000 | 1,851 | - | - | Options (Right to buy) | |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 May 2023 | 25,000 | 26,851 | - | - | Options (Right to buy) | |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 23.14 per share. | 15 May 2023 | 25,000 | 79,543 | - | 23.1 | 578,535 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 23.79 per share. | 15 May 2023 | 25,000 | 79,543 | - | 23.8 | 594,733 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.00 per share. | 15 May 2023 | 25,000 | 104,543 | - | 3 | 75,000 | Common Stock |
| Veeral Desai | Chief Strategy & Dev. Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 May 2023 | 4,500 | 1,510,000 | - | - | Options (Rights to Buy) | |
| Veeral Desai | Chief Strategy & Dev. Officer | Sale of securities on an exchange or to another person at price $ 26.15 per share. | 09 May 2023 | 4,500 | 299,585 | - | 26.1 | 117,666 | Common Stock |
| Veeral Desai | Chief Strategy & Dev. Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.00 per share. | 09 May 2023 | 4,500 | 304,085 | - | 3 | 13,500 | Common Stock |
| Veeral Desai | Chief Strategy & Dev. Officer | Sale of securities on an exchange or to another person at price $ 27.84 per share. | 19 Apr 2023 | 455 | 299,585 | - | 27.8 | 12,666 | Common Stock |
| Veeral Desai | Chief Strategy & Dev. Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Apr 2023 | 500 | 1,514,500 | - | - | Options (Rights to Buy) | |
| Veeral Desai | Chief Strategy & Dev. Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Apr 2023 | 5,000 | 1,515,000 | - | - | Options (Rights to Buy) | |
| Veeral Desai | Chief Strategy & Dev. Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.00 per share. | 19 Apr 2023 | 500 | 300,085 | - | 3 | 1,500 | Common Stock |
| Veeral Desai | Chief Strategy & Dev. Officer | Sale of securities on an exchange or to another person at price $ 26.15 per share. | 19 Apr 2023 | 500 | 299,585 | - | 26.1 | 13,074 | Common Stock |
| Veeral Desai | Chief Strategy & Dev. Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.00 per share. | 19 Apr 2023 | 5,000 | 304,585 | - | 3 | 15,000 | Common Stock |
| Veeral Desai | Chief Strategy & Dev. Officer | Sale of securities on an exchange or to another person at price $ 26.82 per share. | 19 Apr 2023 | 4,545 | 300,040 | - | 26.8 | 121,877 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Apr 2023 | 1,851 | 0 | - | - | Options (Right to buy) | |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Apr 2023 | 25,000 | 51,851 | - | - | Options (Right to buy) | |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Apr 2023 | 23,149 | 76,851 | - | - | Options (Right to buy) | |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 28.05 per share. | 17 Apr 2023 | 25,000 | 79,543 | - | 28.0 | 701,130 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.00 per share. | 17 Apr 2023 | 25,000 | 104,543 | - | 3 | 75,000 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 28.54 per share. | 17 Apr 2023 | 1,400 | 79,543 | - | 28.5 | 39,957 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 27.70 per share. | 17 Apr 2023 | 23,600 | 80,943 | - | 27.7 | 653,640 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.00 per share. | 17 Apr 2023 | 23,149 | 104,543 | - | 3 | 69,447 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.00 per share. | 17 Apr 2023 | 1,851 | 81,394 | - | 1 | 1,851 | Common Stock |
| Jeffrey A. Schwaneke | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2023 | 5,622 | 9,631 | - | 0 | Common Stock | |
| Ronald A. Williams | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2023 | 5,622 | 2,464,414 | - | 0 | Common Stock | |
| Sharad S. Mansukani | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2023 | 5,622 | 1,241,914 | - | 0 | Common Stock | |
| Steven J. Sell | Director, CEO & President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 28.46 per share. | 14 Apr 2023 | 4,216 | 84,079 | - | 28.5 | 119,987 | Common Stock |
| Steven J. Sell | Director, CEO & President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2023 | 39,530 | 88,295 | - | 0 | Common Stock | |
| Steven J. Sell | Director, CEO & President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2023 | 68,348 | 68,348 | - | - | Options (Right to buy) | |
| Karen A. McLoughlin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2023 | 5,622 | 16,047 | - | 0 | Common Stock | |
| Diana L. McKenzie | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2023 | 5,622 | 6,700 | - | 0 | Common Stock | |
| Timothy S. Bensley | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2023 | 18,986 | 18,986 | - | - | Options (Rights to Buy) | |
| Timothy S. Bensley | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 28.46 per share. | 14 Apr 2023 | 2,871 | 35,171 | - | 28.5 | 81,709 | Common Stock |
| Timothy S. Bensley | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2023 | 10,981 | 38,042 | - | 0 | Common Stock | |
| Priscilla Kasenchak | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2023 | 7,595 | 7,595 | - | - | Options (Rights to Buy) | |
| Priscilla Kasenchak | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2023 | 4,393 | 7,745 | - | 0 | Common Stock | |
| Clay Richards | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2023 | 5,622 | 41,214 | - | 0 | Common Stock | |
| John William Wulf | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2023 | 5,622 | 129,014 | - | 0 | Common Stock | |
| Veeral Desai | Chief Strategy & Dev. Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2023 | 45,566 | 45,566 | - | - | Options (Rights to Buy) | |
| Veeral Desai | Chief Strategy & Dev. Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2023 | 26,353 | 303,082 | - | 0 | Common Stock | |
| Veeral Desai | Chief Strategy & Dev. Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 28.46 per share. | 14 Apr 2023 | 3,497 | 299,585 | - | 28.5 | 99,525 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2023 | 4,393 | 59,819 | - | 0 | Common Stock | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 28.46 per share. | 14 Apr 2023 | 1,312 | 58,507 | - | 28.5 | 37,340 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2023 | 7,595 | 7,595 | - | - | Options (Rights to Buy) | |
| Benjamin Shaker | Chief Markets Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2023 | 37,971 | 37,971 | - | - | Options (Rights to Buy) | |
| Benjamin Shaker | Chief Markets Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 28.46 per share. | 14 Apr 2023 | 3,043 | 79,543 | - | 28.5 | 86,604 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2023 | 21,961 | 82,586 | - | 0 | Common Stock | |
| Girish Venkatachaliah | Chief Technology Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 28.46 per share. | 14 Apr 2023 | 1,357 | 36,399 | - | 28.5 | 38,620 | Common Stock |
| Girish Venkatachaliah | Chief Technology Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2023 | 21,961 | 37,756 | - | 0 | Common Stock | |
| Girish Venkatachaliah | Chief Technology Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2023 | 37,971 | 37,971 | - | - | Options (Rights to Buy) | |
| Veeral Desai | Chief Strategy & Dev. Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.00 per share. | 23 Mar 2023 | 22,710 | 299,439 | - | 3 | 68,130 | Common Stock |
| Veeral Desai | Chief Strategy & Dev. Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Mar 2023 | 97,290 | 1,520,000 | - | - | Options (Rights to Buy) | |
| Veeral Desai | Chief Strategy & Dev. Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Mar 2023 | 22,710 | 1,617,290 | - | - | Options (Rights to Buy) | |
| Veeral Desai | Chief Strategy & Dev. Officer | Sale of securities on an exchange or to another person at price $ 28.70 per share. | 23 Mar 2023 | 97,290 | 276,729 | - | 28.7 | 2,792,379 | Common Stock |
| Veeral Desai | Chief Strategy & Dev. Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.00 per share. | 23 Mar 2023 | 97,290 | 374,019 | - | 3 | 291,870 | Common Stock |
| Veeral Desai | Chief Strategy & Dev. Officer | Sale of securities on an exchange or to another person at price $ 28.71 per share. | 23 Mar 2023 | 22,710 | 276,729 | - | 28.7 | 651,911 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 27.84 per share. | 22 Mar 2023 | 8,094 | 55,426 | - | 27.8 | 225,376 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Mar 2023 | 8,094 | 125,000 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Mar 2023 | 8,094 | 133,094 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 28.04 per share. | 22 Mar 2023 | 8,094 | 55,426 | - | 28.0 | 226,978 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.99 per share. | 22 Mar 2023 | 8,094 | 63,520 | - | 9.0 | 72,765 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.99 per share. | 22 Mar 2023 | 8,094 | 63,520 | - | 9.0 | 72,765 | Common Stock |
| Veeral Desai | Chief Strategy & Dev. Officer | Sale of securities on an exchange or to another person at price $ 26.09 per share. | 16 Mar 2023 | 60,000 | 276,729 | - | 26.1 | 1,565,196 | Common Stock |
| Veeral Desai | Chief Strategy & Dev. Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Mar 2023 | 60,000 | 1,640,000 | - | - | Options (Rights to Buy) | |
| Veeral Desai | Chief Strategy & Dev. Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.00 per share. | 16 Mar 2023 | 60,000 | 336,729 | - | 3 | 180,000 | Common Stock |
| John William Wulf | Director | Sale of securities on an exchange or to another person at price $ 23.82 per share. | 15 Mar 2023 | 80,000 | 123,392 | - | 23.8 | 1,905,224 | Common Stock |
| John William Wulf | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2023 | 80,000 | 120,000 | - | - | Options (Rights to Buy) | |
| John William Wulf | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.50 per share. | 15 Mar 2023 | 80,000 | 203,392 | - | 4.5 | 360,000 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 23.81 per share. | 15 Mar 2023 | 55,000 | 55,426 | - | 23.8 | 1,309,424 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2023 | 100,000 | 175,000 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.49 per share. | 15 Mar 2023 | 100,000 | 110,426 | - | 4.5 | 449,000 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2023 | 70,000 | 257,306 | - | - | Options (Right to buy) | |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 26.08 per share. | 15 Mar 2023 | 10,581 | 60,625 | - | 26.1 | 275,965 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 25.65 per share. | 15 Mar 2023 | 9,831 | 71,206 | - | 25.7 | 252,192 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 24.36 per share. | 15 Mar 2023 | 4,588 | 81,037 | - | 24.4 | 111,741 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.00 per share. | 15 Mar 2023 | 25,000 | 85,625 | - | 1 | 25,000 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 23.80 per share. | 15 Mar 2023 | 25,000 | 60,625 | - | 23.8 | 595,075 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 23.81 per share. | 15 Mar 2023 | 35,000 | 85,625 | - | 23.8 | 833,231 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.00 per share. | 15 Mar 2023 | 25,000 | 120,625 | - | 1 | 25,000 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.00 per share. | 15 Mar 2023 | 70,000 | 95,625 | - | 1 | 70,000 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2023 | 25,000 | 1,851 | - | - | Options (Right to buy) | |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Mar 2023 | 25,000 | 26,851 | - | - | Options (Right to buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 24.36 per share. | 07 Mar 2023 | 8,094 | 10,426 | - | 24.4 | 197,197 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Mar 2023 | 8,094 | 141,188 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Mar 2023 | 8,094 | 149,282 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 24.44 per share. | 07 Mar 2023 | 8,094 | 10,426 | - | 24.4 | 197,821 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.99 per share. | 07 Mar 2023 | 8,094 | 18,520 | - | 9.0 | 72,765 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.99 per share. | 07 Mar 2023 | 8,094 | 18,520 | - | 9.0 | 72,765 | Common Stock |
| Diana L. McKenzie | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Feb 2023 | 11,104 | 11,104 | - | - | Options (Rights to Buy) | |
| Diana L. McKenzie | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Feb 2023 | 1,078 | 1,078 | - | 0 | Common Stock | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.99 per share. | 14 Feb 2023 | 25,881 | 36,307 | - | 9.0 | 232,670 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Feb 2023 | 8,094 | 157,376 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Feb 2023 | 25,881 | 165,470 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 22.98 per share. | 14 Feb 2023 | 8,094 | 10,426 | - | 23.0 | 186,028 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.99 per share. | 14 Feb 2023 | 8,094 | 18,520 | - | 9.0 | 72,765 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 22.99 per share. | 14 Feb 2023 | 25,881 | 10,426 | - | 23.0 | 594,877 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 22.98 per share. | 14 Feb 2023 | 50,000 | 25,625 | - | 23.0 | 1,149,060 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.00 per share. | 14 Feb 2023 | 19,594 | 75,625 | - | 1 | 19,594 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.00 per share. | 14 Feb 2023 | 30,406 | 56,031 | - | 3 | 91,218 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Feb 2023 | 28,555 | 51,851 | - | - | Options (Right to buy) | |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Feb 2023 | 19,594 | 80,406 | - | - | Options (Right to buy) | |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Feb 2023 | 30,406 | 0 | - | - | Options (Right to buy) | |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 23.37 per share. | 14 Feb 2023 | 28,555 | 25,625 | - | 23.4 | 667,342 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.00 per share. | 14 Feb 2023 | 28,555 | 54,180 | - | 1 | 28,555 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Feb 2023 | 5,396 | 222,133 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Feb 2023 | 30,782 | 191,351 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.99 per share. | 01 Feb 2023 | 5,396 | 15,822 | - | 9.0 | 48,510 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 21.76 per share. | 01 Feb 2023 | 5,396 | 10,426 | - | 21.8 | 117,420 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.99 per share. | 01 Feb 2023 | 30,782 | 41,208 | - | 9.0 | 276,730 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 22.99 per share. | 01 Feb 2023 | 30,782 | 10,426 | - | 23.0 | 707,561 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 19.73 per share. | 19 Jan 2023 | 10,792 | 10,426 | - | 19.7 | 212,943 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Jan 2023 | 5,396 | 227,529 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Jan 2023 | 10,792 | 232,925 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 19.92 per share. | 19 Jan 2023 | 5,396 | 10,426 | - | 19.9 | 107,496 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.99 per share. | 19 Jan 2023 | 5,396 | 15,822 | - | 9.0 | 48,510 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.99 per share. | 19 Jan 2023 | 10,792 | 21,218 | - | 9.0 | 97,020 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 19.91 per share. | 17 Jan 2023 | 25,722 | 25,625 | - | 19.9 | 512,225 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jan 2023 | 20,723 | 30,406 | - | - | Options (Right to buy) | |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jan 2023 | 25,722 | 51,129 | - | - | Options (Right to buy) | |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 19.78 per share. | 17 Jan 2023 | 20,723 | 25,625 | - | 19.8 | 409,889 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.00 per share. | 17 Jan 2023 | 20,723 | 46,348 | - | 3 | 62,169 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.00 per share. | 17 Jan 2023 | 25,722 | 51,347 | - | 3 | 77,166 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.99 per share. | 05 Jan 2023 | 2,698 | 13,124 | - | 9.0 | 24,255 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jan 2023 | 2,698 | 243,717 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jan 2023 | 2,698 | 246,415 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 15.46 per share. | 05 Jan 2023 | 2,698 | 10,426 | - | 15.5 | 41,702 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.99 per share. | 05 Jan 2023 | 2,698 | 13,124 | - | 9.0 | 24,255 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 15.51 per share. | 05 Jan 2023 | 2,698 | 10,426 | - | 15.5 | 41,845 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Dec 2022 | 4,511 | 275,000 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.99 per share. | 15 Dec 2022 | 887 | 15,824 | - | 9.0 | 7,974 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.49 per share. | 15 Dec 2022 | 4,511 | 14,937 | - | 4.5 | 20,254 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Dec 2022 | 887 | 249,113 | - | - | Options (Rights to Buy) | |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.00 per share. | 14 Dec 2022 | 18,750 | 44,375 | - | 3 | 56,250 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.00 per share. | 14 Dec 2022 | 18,750 | 44,375 | - | 3 | 56,250 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 17.52 per share. | 14 Dec 2022 | 18,750 | 25,625 | - | 17.5 | 328,491 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2022 | 18,750 | 76,851 | - | - | Options (Right to buy) | |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2022 | 18,750 | 95,601 | - | - | Options (Right to buy) | |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 17.26 per share. | 14 Dec 2022 | 18,750 | 25,625 | - | 17.3 | 323,663 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 17.80 per share. | 05 Dec 2022 | 5,398 | 10,426 | - | 17.8 | 96,079 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Dec 2022 | 5,398 | 284,909 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Dec 2022 | 5,398 | 290,307 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 17.72 per share. | 05 Dec 2022 | 5,398 | 10,426 | - | 17.7 | 95,632 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.49 per share. | 05 Dec 2022 | 5,398 | 15,824 | - | 4.5 | 24,237 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.49 per share. | 05 Dec 2022 | 5,398 | 15,824 | - | 4.5 | 24,237 | Common Stock |
| Steven J. Sell | Director, CEO & President | Purchase of securities on an exchange or from another person at price $ 17.14 per share. | 18 Nov 2022 | 2,900 | 2,900 | - | 17.1 | 49,705 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 18.52 per share. | 16 Nov 2022 | 5,396 | 10,426 | - | 18.5 | 99,919 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Nov 2022 | 5,396 | 295,705 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Nov 2022 | 5,396 | 301,101 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 17.43 per share. | 16 Nov 2022 | 5,396 | 10,426 | - | 17.4 | 94,055 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.49 per share. | 16 Nov 2022 | 5,396 | 15,822 | - | 4.5 | 24,228 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.49 per share. | 16 Nov 2022 | 5,396 | 15,822 | - | 4.5 | 24,228 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 18.29 per share. | 16 Nov 2022 | 18,750 | 25,625 | - | 18.3 | 343,009 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Nov 2022 | 18,750 | 114,351 | - | - | Options (Right to buy) | |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Nov 2022 | 18,750 | 133,101 | - | - | Options (Right to buy) | |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 17.17 per share. | 16 Nov 2022 | 18,750 | 25,625 | - | 17.2 | 321,956 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.00 per share. | 16 Nov 2022 | 18,750 | 44,375 | - | 3 | 56,250 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.00 per share. | 16 Nov 2022 | 18,750 | 44,375 | - | 3 | 56,250 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 20.03 per share. | 01 Nov 2022 | 5,396 | 10,426 | - | 20.0 | 108,093 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Nov 2022 | 5,396 | 306,497 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Nov 2022 | 5,396 | 311,893 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 19.53 per share. | 01 Nov 2022 | 5,396 | 10,426 | - | 19.5 | 105,407 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.49 per share. | 01 Nov 2022 | 5,396 | 15,822 | - | 4.5 | 24,228 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.49 per share. | 01 Nov 2022 | 5,396 | 15,822 | - | 4.5 | 24,228 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.00 per share. | 19 Oct 2022 | 20,452 | 46,077 | - | 3 | 61,356 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Oct 2022 | 29,548 | 151,851 | - | - | Options (Right to buy) | |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Oct 2022 | 20,452 | 181,399 | - | - | Options (Right to buy) | |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 20.66 per share. | 19 Oct 2022 | 1,500 | 25,625 | - | 20.7 | 30,991 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 20.35 per share. | 19 Oct 2022 | 28,048 | 27,125 | - | 20.4 | 570,844 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.00 per share. | 19 Oct 2022 | 29,548 | 55,173 | - | 3 | 88,644 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 20.62 per share. | 19 Oct 2022 | 900 | 25,625 | - | 20.6 | 18,555 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 19.84 per share. | 19 Oct 2022 | 19,552 | 26,525 | - | 19.8 | 387,918 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 19.84 per share. | 19 Oct 2022 | 19,552 | 26,525 | - | 19.8 | 387,918 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 20.62 per share. | 19 Oct 2022 | 900 | 25,625 | - | 20.6 | 18,555 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 20.35 per share. | 19 Oct 2022 | 28,048 | 27,125 | - | 20.4 | 570,844 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 20.66 per share. | 19 Oct 2022 | 1,500 | 25,625 | - | 20.7 | 30,991 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.49 per share. | 14 Oct 2022 | 5,396 | 15,822 | - | 4.5 | 24,228 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Oct 2022 | 5,396 | 317,289 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Oct 2022 | 5,396 | 322,685 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 21.79 per share. | 14 Oct 2022 | 5,396 | 10,426 | - | 21.8 | 117,578 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.49 per share. | 14 Oct 2022 | 5,396 | 15,822 | - | 4.5 | 24,228 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 21.79 per share. | 14 Oct 2022 | 5,396 | 10,426 | - | 21.8 | 117,577 | Common Stock |
| Priscilla Kasenchak | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Oct 2022 | 3,352 | 3,352 | - | 0 | Common Stock | |
| Priscilla Kasenchak | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Oct 2022 | 5,413 | 5,413 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Oct 2022 | 8,094 | 336,175 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 24.27 per share. | 03 Oct 2022 | 8,094 | 10,426 | - | 24.3 | 196,466 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.49 per share. | 03 Oct 2022 | 8,094 | 18,520 | - | 4.5 | 36,342 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 23.17 per share. | 03 Oct 2022 | 8,094 | 10,426 | - | 23.2 | 187,503 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.49 per share. | 03 Oct 2022 | 8,094 | 18,520 | - | 4.5 | 36,342 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Oct 2022 | 8,094 | 328,081 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 22.62 per share. | 26 Sep 2022 | 5,396 | 10,853 | - | 22.6 | 122,072 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Sep 2022 | 10,792 | 344,269 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Sep 2022 | 5,396 | 355,061 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 22.98 per share. | 26 Sep 2022 | 10,792 | 10,853 | - | 23.0 | 247,971 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.49 per share. | 26 Sep 2022 | 10,792 | 21,645 | - | 4.5 | 48,456 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.49 per share. | 26 Sep 2022 | 5,396 | 16,249 | - | 4.5 | 24,228 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.49 per share. | 08 Sep 2022 | 13,490 | 24,343 | - | 4.5 | 60,570 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Sep 2022 | 8,094 | 360,457 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Sep 2022 | 13,490 | 368,551 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 23.08 per share. | 08 Sep 2022 | 8,094 | 10,853 | - | 23.1 | 186,791 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.49 per share. | 08 Sep 2022 | 8,094 | 18,947 | - | 4.5 | 36,342 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 23.02 per share. | 08 Sep 2022 | 2,944 | 10,853 | - | 23.0 | 67,779 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 22.56 per share. | 08 Sep 2022 | 10,546 | 13,797 | - | 22.6 | 237,897 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.49 per share. | 23 Aug 2022 | 5,396 | 16,249 | - | 4.5 | 24,228 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Aug 2022 | 5,396 | 382,041 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Aug 2022 | 5,396 | 387,437 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 20.90 per share. | 23 Aug 2022 | 5,396 | 10,853 | - | 20.9 | 112,775 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.49 per share. | 23 Aug 2022 | 5,396 | 16,249 | - | 4.5 | 24,228 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 20.49 per share. | 23 Aug 2022 | 5,396 | 10,853 | - | 20.5 | 110,553 | Common Stock |
| Jeffrey A. Schwaneke | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Aug 2022 | 9,680 | 9,680 | - | - | Options (Rights to Buy) | |
| Jeffrey A. Schwaneke | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Aug 2022 | 4,009 | 4,009 | - | 0 | Common Stock | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 26.09 per share. | 04 Aug 2022 | 8,094 | 10,853 | - | 26.1 | 211,145 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Aug 2022 | 8,094 | 392,833 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Aug 2022 | 8,094 | 400,927 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 23.96 per share. | 04 Aug 2022 | 8,094 | 10,853 | - | 24.0 | 193,927 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.49 per share. | 04 Aug 2022 | 8,094 | 18,947 | - | 4.5 | 36,342 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.49 per share. | 04 Aug 2022 | 8,094 | 18,947 | - | 4.5 | 36,342 | Common Stock |
| Veeral Desai | Chief Strategy & Dev. Officer | Sale of securities on an exchange or to another person at price $ 27.50 per share. | 21 Jul 2022 | 79,768 | 278,211 | - | 27.5 | 2,193,620 | Common Stock |
| Veeral Desai | Chief Strategy & Dev. Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Jul 2022 | 79,768 | 57,441 | - | - | Options (Rights to Buy) | |
| Veeral Desai | Chief Strategy & Dev. Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.00 per share. | 21 Jul 2022 | 79,768 | 357,979 | - | 1 | 79,768 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 27.63 per share. | 20 Jul 2022 | 39,052 | 38,080 | - | 27.6 | 1,078,839 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 26.35 per share. | 20 Jul 2022 | 45,442 | 32,014 | - | 26.4 | 1,197,465 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 26.68 per share. | 20 Jul 2022 | 4,558 | 27,456 | - | 26.7 | 121,614 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.00 per share. | 20 Jul 2022 | 49,676 | 77,132 | - | 1 | 49,676 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 28.04 per share. | 20 Jul 2022 | 10,948 | 27,132 | - | 28.0 | 307,011 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Jul 2022 | 49,676 | 327,306 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.49 per share. | 15 Jul 2022 | 8,094 | 18,947 | - | 4.5 | 36,342 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2022 | 8,094 | 409,021 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2022 | 8,094 | 417,115 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 26.57 per share. | 15 Jul 2022 | 8,094 | 10,853 | - | 26.6 | 215,090 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.49 per share. | 15 Jul 2022 | 8,094 | 18,947 | - | 4.5 | 36,342 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 26.25 per share. | 15 Jul 2022 | 8,094 | 10,853 | - | 26.2 | 212,429 | Common Stock |
| Veeral Desai | Chief Strategy & Dev. Officer | Sale of securities on an exchange or to another person at price $ 25.00 per share. | 07 Jul 2022 | 319,071 | 278,211 | - | 25 | 7,976,775 | Common Stock |
| Veeral Desai | Chief Strategy & Dev. Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jul 2022 | 319,071 | 137,209 | - | - | Options (Rights to Buy) | |
| Veeral Desai | Chief Strategy & Dev. Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.00 per share. | 07 Jul 2022 | 319,071 | 597,282 | - | 1 | 319,071 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 21.88 per share. | 01 Jul 2022 | 5,396 | 10,853 | - | 21.9 | 118,040 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2022 | 41,187 | 425,209 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2022 | 5,396 | 466,396 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 23.07 per share. | 01 Jul 2022 | 35,791 | 10,853 | - | 23.1 | 825,570 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 22.25 per share. | 01 Jul 2022 | 5,396 | 46,644 | - | 22.2 | 120,052 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.49 per share. | 01 Jul 2022 | 41,187 | 52,040 | - | 4.5 | 184,930 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.49 per share. | 01 Jul 2022 | 5,396 | 16,249 | - | 4.5 | 24,228 | Common Stock |
| Veeral Desai | Chief Strategy & Dev. Officer | Sale of securities on an exchange or to another person at price $ 22.50 per share. | 24 Jun 2022 | 106,357 | 278,211 | - | 22.5 | 2,393,033 | Common Stock |
| Veeral Desai | Chief Strategy & Dev. Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jun 2022 | 106,357 | 456,280 | - | - | Options (Rights to Buy) | |
| Veeral Desai | Chief Strategy & Dev. Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.00 per share. | 24 Jun 2022 | 106,357 | 384,568 | - | 1 | 106,357 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 19.88 per share. | 22 Jun 2022 | 5,396 | 10,853 | - | 19.9 | 107,256 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Jun 2022 | 5,396 | 471,792 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Jun 2022 | 5,396 | 477,188 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 20.08 per share. | 22 Jun 2022 | 5,396 | 10,853 | - | 20.1 | 108,365 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.49 per share. | 22 Jun 2022 | 5,396 | 16,249 | - | 4.5 | 24,228 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.49 per share. | 22 Jun 2022 | 5,396 | 16,249 | - | 4.5 | 24,228 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Jun 2022 | 5,396 | 482,584 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Jun 2022 | 5,396 | 487,980 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 19.33 per share. | 09 Jun 2022 | 5,396 | 10,853 | - | 19.3 | 104,296 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.49 per share. | 09 Jun 2022 | 5,396 | 16,249 | - | 4.5 | 24,228 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 20.90 per share. | 09 Jun 2022 | 5,396 | 10,853 | - | 20.9 | 112,767 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.49 per share. | 09 Jun 2022 | 5,396 | 16,249 | - | 4.5 | 24,228 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.49 per share. | 27 May 2022 | 5,396 | 16,249 | - | 4.5 | 24,228 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 May 2022 | 5,396 | 493,376 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 May 2022 | 5,396 | 498,772 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 19.77 per share. | 27 May 2022 | 5,396 | 10,853 | - | 19.8 | 106,679 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.49 per share. | 27 May 2022 | 5,396 | 16,249 | - | 4.5 | 24,228 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 19.58 per share. | 27 May 2022 | 5,396 | 10,853 | - | 19.6 | 105,642 | Common Stock |
| Michael L. Smith | Director | Sale of securities on an exchange or to another person at price $ 19.53 per share. | 25 May 2022 | 145,874 | 4,126 | - | 19.5 | 2,849,459 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 16.42 per share. | 10 May 2022 | 5,096 | 11,153 | - | 16.4 | 83,687 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 May 2022 | 5,396 | 504,168 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.49 per share. | 10 May 2022 | 5,396 | 16,249 | - | 4.5 | 24,228 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 May 2022 | 5,396 | 509,564 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 15.95 per share. | 10 May 2022 | 5,396 | 10,853 | - | 16.0 | 86,070 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.49 per share. | 10 May 2022 | 5,396 | 16,249 | - | 4.5 | 24,228 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 17.26 per share. | 10 May 2022 | 300 | 10,853 | - | 17.3 | 5,177 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Apr 2022 | 5,396 | 520,356 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Apr 2022 | 5,396 | 514,960 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 18.30 per share. | 27 Apr 2022 | 5,396 | 10,853 | - | 18.3 | 98,737 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.49 per share. | 27 Apr 2022 | 5,396 | 16,249 | - | 4.5 | 24,228 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 18.68 per share. | 27 Apr 2022 | 5,396 | 10,853 | - | 18.7 | 100,773 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.49 per share. | 27 Apr 2022 | 5,396 | 16,249 | - | 4.5 | 24,228 | Common Stock |
| Veeral Desai | Chief Strategy & Dev. Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Apr 2022 | 79,568 | 589,426 | - | - | Options (Rights to Buy) | |
| Veeral Desai | Chief Strategy & Dev. Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Apr 2022 | 26,789 | 562,637 | - | - | Options (Rights to Buy) | |
| Veeral Desai | Chief Strategy & Dev. Officer | Sale of securities on an exchange or to another person at price $ 20.00 per share. | 21 Apr 2022 | 26,789 | 278,211 | - | 20 | 535,780 | Common Stock |
| Veeral Desai | Chief Strategy & Dev. Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.00 per share. | 21 Apr 2022 | 26,789 | 305,000 | - | 1 | 26,789 | Common Stock |
| Veeral Desai | Chief Strategy & Dev. Officer | Sale of securities on an exchange or to another person at price $ 21.35 per share. | 21 Apr 2022 | 9,744 | 278,211 | - | 21.3 | 207,989 | Common Stock |
| Veeral Desai | Chief Strategy & Dev. Officer | Sale of securities on an exchange or to another person at price $ 20.43 per share. | 21 Apr 2022 | 69,824 | 287,955 | - | 20.4 | 1,426,183 | Common Stock |
| Veeral Desai | Chief Strategy & Dev. Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.00 per share. | 21 Apr 2022 | 79,568 | 357,779 | - | 1 | 79,568 | Common Stock |
| Veeral Desai | Chief Strategy & Dev. Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Apr 2022 | 106,357 | 775,351 | - | - | Options (Rights to Buy) | |
| Veeral Desai | Chief Strategy & Dev. Officer | Sale of securities on an exchange or to another person at price $ 22.34 per share. | 19 Apr 2022 | 106,357 | 278,211 | - | 22.3 | 2,376,015 | Common Stock |
| Veeral Desai | Chief Strategy & Dev. Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Apr 2022 | 106,357 | 668,994 | - | - | Options (Rights to Buy) | |
| Veeral Desai | Chief Strategy & Dev. Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.00 per share. | 19 Apr 2022 | 106,357 | 384,568 | - | 1 | 106,357 | Common Stock |
| Veeral Desai | Chief Strategy & Dev. Officer | Sale of securities on an exchange or to another person at price $ 22.74 per share. | 19 Apr 2022 | 106,357 | 278,211 | - | 22.7 | 2,418,558 | Common Stock |
| Veeral Desai | Chief Strategy & Dev. Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.00 per share. | 19 Apr 2022 | 106,357 | 384,568 | - | 1 | 106,357 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Apr 2022 | 6,477 | 532,048 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Apr 2022 | 6,296 | 525,752 | - | - | Options (Rights to Buy) | |
| Michael L. Smith | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2022 | 6,936 | 158,992 | - | 0 | Common Stock | |
| Ronald A. Williams | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2022 | 6,936 | 2,458,792 | - | 0 | Common Stock | |
| Sharad S. Mansukani | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2022 | 6,936 | 1,236,292 | - | 0 | Common Stock | |
| Steven J. Sell | Director, CEO & President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2022 | 160,486 | 160,486 | - | - | Options (Rights to Buy) | |
| Steven J. Sell | Director, CEO & President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2022 | 48,765 | 48,765 | - | 0 | Common Stock | |
| Karen A. McLoughlin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2022 | 6,936 | 10,425 | - | 0 | Common Stock | |
| Timothy S. Bensley | Chief Financial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 23.07 per share. | 14 Apr 2022 | 1,430 | 27,061 | - | 23.1 | 32,990 | Common Stock |
| Michelle A. Gourdine | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2022 | 6,936 | 18,892 | - | 0 | Common Stock | |
| Clay Richards | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2022 | 6,936 | 35,592 | - | 0 | Common Stock | |
| John William Wulf | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2022 | 6,936 | 123,392 | - | 0 | Common Stock | |
| Veeral Desai | Chief Strategy & Dev. Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 23.07 per share. | 14 Apr 2022 | 1,482 | 276,729 | - | 23.1 | 34,190 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 23.07 per share. | 14 Apr 2022 | 427 | 10,426 | - | 23.1 | 9,851 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 23.07 per share. | 14 Apr 2022 | 1,507 | 25,625 | - | 23.1 | 34,766 | Common Stock |
| Girish Venkatachaliah | Chief Technology Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 23.07 per share. | 14 Apr 2022 | 476 | 15,795 | - | 23.1 | 10,981 | Common Stock |
| Glenn Sobotka | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 23.07 per share. | 14 Apr 2022 | 334 | 5,365 | - | 23.1 | 7,705 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 25.01 per share. | 07 Apr 2022 | 2,706 | 63,910 | - | 25.0 | 67,677 | Common Stock |
| Veeral Desai | Chief Strategy & Dev. Officer | Sale of securities on an exchange or to another person at price $ 20.41 per share. | 16 Mar 2022 | 197,291 | 261,956 | - | 20.4 | 4,026,709 | Common Stock |
| Veeral Desai | Chief Strategy & Dev. Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Mar 2022 | 197,291 | 899,597 | - | - | Options (Right to buy) | |
| Veeral Desai | Chief Strategy & Dev. Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.00 per share. | 16 Mar 2022 | 197,291 | 459,247 | - | 1 | 197,291 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 20.20 per share. | 16 Mar 2022 | 37,155 | 66,616 | - | 20.2 | 750,531 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Mar 2022 | 37,155 | 201,851 | - | - | Options (Right to buy) | |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.00 per share. | 16 Mar 2022 | 37,155 | 103,771 | - | 3 | 111,465 | Common Stock |
| John William Wulf | Director | Sale of securities on an exchange or to another person at price $ 19.13 per share. | 15 Mar 2022 | 11,100 | 136,164 | - | 19.1 | 212,343 | Common Stock |
| John William Wulf | Director | Sale of securities on an exchange or to another person at price $ 19.08 per share. | 15 Mar 2022 | 19,708 | 116,456 | - | 19.1 | 376,029 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Mar 2022 | 81,537 | 318,463 | - | - | Options (Right to buy) | |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 19.25 per share. | 14 Mar 2022 | 79,457 | 66,616 | - | 19.2 | 1,529,547 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Mar 2022 | 79,457 | 239,006 | - | - | Options (Right to buy) | |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 21.25 per share. | 14 Mar 2022 | 30,867 | 66,616 | - | 21.3 | 655,924 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 19.64 per share. | 14 Mar 2022 | 34,910 | 113,243 | - | 19.6 | 685,632 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.00 per share. | 14 Mar 2022 | 81,537 | 148,153 | - | 3 | 244,611 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 3.00 per share. | 14 Mar 2022 | 79,457 | 146,073 | - | 3 | 238,371 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 20.60 per share. | 14 Mar 2022 | 15,760 | 97,483 | - | 20.6 | 324,656 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 26.54 per share. | 28 Dec 2021 | 4,685 | 66,616 | - | 26.5 | 124,340 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 26.72 per share. | 28 Dec 2021 | 14,055 | 71,301 | - | 26.7 | 375,550 | Common Stock |
| Theodore Halkias | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Dec 2021 | 5,583 | 1,714,722 | - | - | Options (Rights to Buy) | |
| Theodore Halkias | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Dec 2021 | 21,142 | 1,720,305 | - | - | Options (Rights to Buy) | |
| Theodore Halkias | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 27.53 per share. | 23 Dec 2021 | 5,583 | 5,434 | - | 27.5 | 153,700 | Common Stock |
| Theodore Halkias | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 27.52 per share. | 23 Dec 2021 | 21,142 | 5,434 | - | 27.5 | 581,828 | Common Stock |
| Theodore Halkias | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.00 per share. | 23 Dec 2021 | 5,583 | 11,017 | - | 1 | 5,583 | Common Stock |
| Theodore Halkias | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.00 per share. | 23 Dec 2021 | 21,142 | 26,576 | - | 1 | 21,142 | Common Stock |
| Joan Danieley | Chief Administrative Officer | Sale of securities on an exchange or to another person at price $ 22.97 per share. | 17 Dec 2021 | 18,593 | 5,434 | - | 23.0 | 427,081 | Common Stock |
| Joan Danieley | Chief Administrative Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.45 per share. | 17 Dec 2021 | 21,481 | 26,915 | - | 4.4 | 95,590 | Common Stock |
| Joan Danieley | Chief Administrative Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Dec 2021 | 21,481 | 50,000 | - | - | Options (Rights to Buy) | |
| Joan Danieley | Chief Administrative Officer | Sale of securities on an exchange or to another person at price $ 22.27 per share. | 17 Dec 2021 | 2,888 | 24,027 | - | 22.3 | 64,316 | Common Stock |
| Joan Danieley | Chief Administrative Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.45 per share. | 15 Dec 2021 | 25,000 | 30,434 | - | 4.5 | 111,250 | Common Stock |
| Joan Danieley | Chief Administrative Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Dec 2021 | 3,519 | 71,481 | - | - | Options (Rights to Buy) | |
| Joan Danieley | Chief Administrative Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Dec 2021 | 25,000 | 75,000 | - | - | Options (Rights to Buy) | |
| Joan Danieley | Chief Administrative Officer | Sale of securities on an exchange or to another person at price $ 23.14 per share. | 15 Dec 2021 | 3,519 | 5,434 | - | 23.1 | 81,430 | Common Stock |
| Joan Danieley | Chief Administrative Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.45 per share. | 15 Dec 2021 | 3,519 | 8,953 | - | 4.5 | 15,660 | Common Stock |
| Joan Danieley | Chief Administrative Officer | Sale of securities on an exchange or to another person at price $ 23.29 per share. | 15 Dec 2021 | 9,679 | 5,434 | - | 23.3 | 225,424 | Common Stock |
| Joan Danieley | Chief Administrative Officer | Sale of securities on an exchange or to another person at price $ 22.58 per share. | 15 Dec 2021 | 15,321 | 15,113 | - | 22.6 | 345,948 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 25.26 per share. | 16 Nov 2021 | 4,685 | 85,356 | - | 25.3 | 118,343 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 25.37 per share. | 16 Nov 2021 | 4,685 | 90,041 | - | 25.4 | 118,858 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 25.19 per share. | 04 Nov 2021 | 18,560 | 94,726 | - | 25.2 | 467,526 | Common Stock |
| Glenn Sobotka | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.57 per share. | 04 Nov 2021 | 150,000 | 153,260 | - | 7.6 | 1,135,500 | Common Stock |
| Glenn Sobotka | Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Nov 2021 | 150,000 | 0 | - | - | Options (Rights to Buy) | |
| Glenn Sobotka | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 25.19 per share. | 04 Nov 2021 | 150,000 | 3,260 | - | 25.2 | 3,778,500 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 25.00 per share. | 03 Nov 2021 | 300 | 113,286 | - | 25 | 7,500 | Common Stock |
| Sharad Mansukani | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.00 per share. | 14 Sep 2021 | 156,250 | 1,385,606 | - | 1 | 156,250 | Common Stock |
| Sharad Mansukani | Director | Sale of securities on an exchange or to another person at price $ 28.98 per share. | 14 Sep 2021 | 156,250 | 1,229,356 | - | 29.0 | 4,528,125 | Common Stock |
| Sharad Mansukani | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Sep 2021 | 156,250 | 493,750 | - | - | Options (Rights to Buy) | |
| Steven J. Sell | Director, CEO & President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.50 per share. | 14 Sep 2021 | 100,000 | 100,000 | - | 4.5 | 450,000 | Common Stock |
| Steven J. Sell | Director, CEO & President | Sale of securities on an exchange or to another person at price $ 28.98 per share. | 14 Sep 2021 | 100,000 | 0 | - | 29.0 | 2,898,000 | Common Stock |
| Steven J. Sell | Director, CEO & President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Sep 2021 | 100,000 | 900,000 | - | - | Options (Rights to Buy) | |
| John William Wulf | Director | Sale of securities on an exchange or to another person at price $ 28.98 per share. | 14 Sep 2021 | 15,342 | 147,264 | - | 29.0 | 444,611 | Common Stock |
| Theodore Halkias | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.00 per share. | 14 Sep 2021 | 58,553 | 63,987 | - | 1 | 58,553 | Common Stock |
| Theodore Halkias | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 28.98 per share. | 14 Sep 2021 | 100,000 | 0 | - | 29.0 | 2,898,000 | Common Stock |
| Theodore Halkias | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 28.98 per share. | 14 Sep 2021 | 58,553 | 5,434 | - | 29.0 | 1,696,866 | Common Stock |
| Theodore Halkias | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Sep 2021 | 58,553 | 1,741,447 | - | - | Options (Rights to Buy) | |
| Veeral Desai | Chief Strategy & Dev. Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Sep 2021 | 121,001 | 1,078,999 | - | - | Options (Rights to Buy) | |
| Veeral Desai | Chief Strategy & Dev. Officer | Sale of securities on an exchange or to another person at price $ 28.98 per share. | 14 Sep 2021 | 121,001 | 261,956 | - | 29.0 | 3,506,609 | Common Stock |
| Veeral Desai | Chief Strategy & Dev. Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.00 per share. | 14 Sep 2021 | 121,001 | 382,957 | - | 1 | 121,001 | Common Stock |
| Lisa Dombro | Exper. & Innovation Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Sep 2021 | 61,543 | 438,457 | - | - | Options (Rights to Buy) | |
| Lisa Dombro | Exper. & Innovation Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.00 per share. | 14 Sep 2021 | 61,543 | 73,499 | - | 1 | 61,543 | Common Stock |
| Lisa Dombro | Exper. & Innovation Officer | Sale of securities on an exchange or to another person at price $ 28.98 per share. | 14 Sep 2021 | 61,543 | 11,956 | - | 29.0 | 1,783,516 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Sep 2021 | 11,475 | 538,525 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Sale of securities on an exchange or to another person at price $ 28.98 per share. | 14 Sep 2021 | 11,475 | 5,434 | - | 29.0 | 332,546 | Common Stock |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 4.50 per share. | 14 Sep 2021 | 11,475 | 16,909 | - | 4.5 | 51,638 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.00 per share. | 14 Sep 2021 | 73,018 | 186,604 | - | 1 | 73,018 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Sale of securities on an exchange or to another person at price $ 28.98 per share. | 14 Sep 2021 | 73,018 | 113,586 | - | 29.0 | 2,116,062 | Common Stock |
| Benjamin Shaker | Chief Markets Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Sep 2021 | 73,018 | 376,982 | - | - | Options (Rights to Buy) | |
| Richard J. Schnall | Director | Other type of transaction at price $ 0.00 per share. | 09 Sep 2021 | 119,989 | 119,989 | - | 0 | Common Stock | |
| Richard J. Schnall | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 09 Sep 2021 | 119,989 | 0 | - | 0 | Common Stock | |
| Karen A. McLoughlin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jul 2021 | 7,959 | 7,959 | - | - | Options (Rights to Buy) | |
| Karen A. McLoughlin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jul 2021 | 3,489 | 3,489 | - | 0 | Common Stock | |
| Michelle A. Gourdine | Director | Purchase of securities on an exchange or from another person at price $ 23.00 per share. | 19 Apr 2021 | 5,000 | 11,956 | - | 23 | 115,000 | Common Stock |
| Clay Richards | Director | Purchase of securities on an exchange or from another person at price $ 23.00 per share. | 19 Apr 2021 | 21,700 | 28,656 | - | 23 | 499,100 | Common Stock |
| Michael L. Smith | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2021 | 6,956 | 152,056 | - | 0 | Common Stock | |
| Ronald A. Williams | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2021 | 6,956 | 2,451,856 | - | 0 | Common Stock | |
| Sharad Mansukani | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2021 | 6,956 | 1,229,356 | - | 0 | Common Stock | |
| Timothy S. Bensley | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2021 | 14,945 | 14,945 | - | 0 | Common Stock | |
| Timothy S. Bensley | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2021 | 217,431 | 217,431 | - | - | Options (Rights to Buy) | |
| Michelle A. Gourdine | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2021 | 11,843 | 11,843 | - | - | Options (Rights to Buy) | |
| Michelle A. Gourdine | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2021 | 6,956 | 6,956 | - | 0 | Common Stock | |
| Clay Richards | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2021 | 11,843 | 11,843 | - | - | Options (Rights to Buy) | |
| Clay Richards | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2021 | 6,956 | 6,956 | - | 0 | Common Stock | |
| John William Wulf | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2021 | 6,956 | 127,556 | - | 0 | Common Stock | |
| Theodore Halkias | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2021 | 18,504 | 18,504 | - | - | Options (Rights to Buy) | |
| Theodore Halkias | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2021 | 5,434 | 5,434 | - | 0 | Common Stock | |
| Veeral Desai | Chief Strategy & Dev. Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2021 | 40,710 | 40,710 | - | - | Options (Rights to Buy) | |
| Veeral Desai | Chief Strategy & Dev. Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2021 | 11,956 | 261,956 | - | 0 | Common Stock | |
| Lisa Dombro | Exper. & Innovation Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2021 | 40,710 | 40,710 | - | - | Options (Rights to Buy) | |
| Lisa Dombro | Exper. & Innovation Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2021 | 11,956 | 11,956 | - | 0 | Common Stock | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2021 | 18,504 | 18,504 | - | - | Options (Rights to Buy) | |
| Benjamin Kornitzer | Chief Med. & Quality Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2021 | 5,434 | 5,434 | - | 0 | Common Stock | |
| Joan Danieley | Chief Administrative Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2021 | 18,504 | 18,504 | - | - | Options (Rights to Buy) | |
| Joan Danieley | Chief Administrative Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2021 | 5,434 | 5,434 | - | 0 | Common Stock | |
| Benjamin Shaker | Chief Markets Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2021 | 46,262 | 46,262 | - | - | Options (Rights to Buy) | |
| Benjamin Shaker | Chief Markets Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2021 | 13,586 | 113,586 | - | 0 | Common Stock | |
| Girish Venkatachaliah | Chief Technology Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Apr 2021 | 5,434 | 5,434 | - | 0 | Common Stock |